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Microglial activation occurs late during preclinical alzheimers disease

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doi:10.1093/carcin/bgn178

doi: 10.1016/j.neurol.2011.01.011

Choline serves as a precursor to phosphatidylcholine (a major cell membrane component) and to the neurotransmitter acetylcholine, involved in memory, muscle control, and mood

Using these enzyme preparations with a defined GSH concentration (20 M) in the established two-step in vitro reactions, we found that the extent of conversion of the ultrafiltered flavan-3,3,4-triol ( 4 ) depended on the applied concentration of the purified Pt GSTF8, confirming that this enzyme is required and sufficient for the observed conversion to cyanidin (Extended Data Fig