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16 The aim of this paper is to review the evidence for the use of B12 in clinical practice beyond the replacement in deficiency

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Although it is a transmembrane protein, it can be found in the circulation, at the expense of proteolytic cleavage of its extracellular region

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Nutrient absorption, immune function, hormone signaling, neurotransmitter production (about 90% of serotonin is made in the gut), and systemic inflammation levels are all tied to gut integrity