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Intrinsically, neurons are at risk for oxidative damage as their redox potential remains low due to a poor de novo synthesis of GSH caused by a weak expression of Nrf2 in neurons compared to astrocytes (Bolaos 2016)

10.1016/j.mam.2015.01.001 203 SwisaA.GranotZ.TamarinaN.SayersS.BardeesyN.PhilipsonL.et al (2015)

Animals As a model species, we used 7-day-old BALB/c mice

Briefly, a stock solution for PM1-8 was prepared by adding 5 mL of His (2.4 mg/mL), Trp (4.8 mg/mL), Ura (2.4 mg/mL), and Leu (7.2 mg/mL) to 580 mL of ddH 2 O

Lp-PLA2 cleaves oxidized PE-AA, 1-steaoryl-2-15-HpETE- sn -glycero-3-phosphatidylethanolamine (SAPE-OOH) in a manner analogous to that of iPLA2 69

Because signal transduction regulates metabolism and because metabolites modulate signaling, information on a few selected aspects of signaling will be included in these sections