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The rate of GSH synthesis is dependent upon the availability of cysteine and the activity of the rate-limiting enzyme, -glutamylcysteine synthetase (also called glutamate-cysteine ligase, GCL)

Because RLS is akin to some other movement disorders the neurotransmitter dopamine , which helps facilitate uniform, controlled movements, has been theorized to be a possible causative factor

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Furthermore, by improving NO bioavailability, these supplements help alleviate the metabolic crisis associated with mitochondrial dysfunction, thus reducing lactic acidosis and enhancing overall cellular energy metabolism [66]