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Deepika, Maurya PK
This effect is primarily attributed to methylxanthines, such as theobromine, which induces LES relaxation through a mechanism similar to caffeine (Reference Fredholm190)

Yang J, Tong TT, Zhu CH, Zhou M, Jiang YQ, Chen H, et al

10.1073/pnas.1203567109 Proc

doi: 10.1073/pnas.2021798118 198 ZhangB.WanY

Development of the 503B Bulks List has been underway with the FDA
