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Flavonoids may have intramolecular hydrogen bonds that decrease the antioxidant activity of hydroxyl groups when acting as hydrogen bond donors (5 OH, 3 OH and 3 OH, Figure 3) while enhancing the antioxidant activity of hydroxyl groups, acting as hydrogen bond acceptors (4 OH, Figure 3)

10.1128/mSphere.00074-16 249 UnderhillD

Treatment of diabetic sensory polyneuropathy

However, there are now ways and means of arming yourself for such cases

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