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As the original name implies, PLPP4 and PLPP5 prefer diacylglycerol pyrophosphate (DGPP) as a substrate but they also hydrolyze phosphatidic acid (PA) and lysophosphatidic acid (LPA)

Moreover, it was established that CRP exacerbates acute kidney injury in mice, and this was associated with the heightened renal accumulation of myeloid-derived cells with suppressor functions, with a research study revealing CRPs ability to expand and trigger the increased FcRIIb-independent production of iROS in these cells, as well as its ability to FcRIIb-dependently enhance the T cell-suppressive action [154]

The amount and purity were tested using a Nanodrop (UV-Vis spectrophotometer Q5000/USA), and the integrity was evaluated using gel electrophoresis

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