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Phenylephrine, an -adrenergic agonist present in one formulation, constricts superficial vessels, decreasing perfusion, limiting drug washout, and extending local anesthetic residence time while reducing procedural bleeding

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In biological systems, hydroxyl radicals can be formed by homolytic cleavage of water using high-energy irradiation or more probably, by redox metal-catalyzed decomposition of hydrogen peroxide (reaction 7, Fenton reaction)

Incorporation of multiple metals into a single nanoplatform further amplifies ROS generation and synergistic therapies like PDT, CDT, and PTT [79]

This non-targeted approach enables large-scale complex sample quantification