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These phospholipids readily undergo Fe + -dependent lipid peroxidation, creating a pro-ferroptotic microenvironment ( 4-Hydroxynonenal (4-HNE), a characteristic end-product of -6 polyunsaturated fatty acid (e.g., arachidonic acid) lipid peroxidation, serves as a key molecular biomarker of ferroptosis ( Cumulatively, the core mechanism of ferroptosis involves synergistic amplification of lipid peroxidation cascades through multiple feedback loops

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Propionylcarnitine (C3) and its ratios with acetylcarnitine (C3/C2) and palmitoylcarnitine (C3/C16) In addition to the four canonical markers discussed above, vitamin B 12 deficiency leads to accumulation of propionylcarnitine (C3) (Sarafoglou et al., 2011), which is a marker of methylmalonic aciduria and propionic acidemia

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