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This is a clean, easy-to-measure setup

( Epub 2020 Mar 4 )

Infection susceptibility in gastric intrinsic factor (Vitamin B12)-defective mice is subject to maternal influences

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Vitamin B 1 deficiency causes overexpression of pro-inflammatory cytokines such as interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha (TNF-) as well as increased expression of CD40 and CD40 ligand by microglial cells and astrocytes, which eventually leads to the death of neuron cells [18,19]

Taken together, these data support the development of a phase I clinical trial of BSO+myeloablative dosing of L-PAM and stem cell support in patients with relapsed and refractory MM
