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Farhats study pointed out that the oxidative capacity of the gastrocnemius muscle in female Wistar rats is higher, with greater mitochondrial respiration in states 3 and 4, enhanced enzyme activity in certain electron transport chain complexes, and higher protein content of cytochrome c oxidase

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2 Animal models for CIPN studies Animal models are frequently used to study the pathogenesis of CIPN and more importantly, to evaluate the drug efficacy in preventing or reversing CIPN symptoms (Hoke and Ray, 2014)

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This was accompanied by a significant increase in pro-inflammatory cytokines, including IL-1, IL-18, and TNF-