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Intriguingly, IL-5- or GM-CSF-primed eosinophils have been shown to be more sensitive to Siglec-8-induced apoptosis ( 5 Corticosteroid-induced eosinophil apoptosis Corticosteroids, such as dexamethasone, induce the mitochondrial pathway of apoptosis in eosinophils, which contributes to the resolution of airway inflammation (Milara et al., 2023)

In agreement, we found an increase in ATF6 in the DJ1 L166P cells, which increases activation due to the accumulation of misfolded products, leading to the induction of inflammatory gene networks 66

Microbiome, 4:1-12

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Hade et al