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As mentioned previously, several studies have reported that brain GSH levels are reduced following TBI and genetic variations in GSH-dependent, peroxide/electrophile-detoxifying enzymes, such as glutathione-S-tranferase-4 and glutathione peroxidase-1, can sensitize mice and rats to brain injury induced by TBI (Tyurin et al., 2000

Mangiferin directly binds to Keap1, activates the downstream Nrf2/SLC7A11/GPX4 pathway, inhibits osteoblast ferroptosis, promotes bone formation and improves osteoporosis in ovariectomized mice and iron overload mice

(Oxf) 82 (5), 624632

A thorough understanding of the p53 functional network will be extremely useful in future strategies to identify pharmacological targets for cancer therapy

Consequently, animals reduce metabolism by lowering CoA levels and suppressing protein synthesis, avoiding the rapid release of cytotoxic cysteine

[DOI] [PubMed] [Google Scholar] 137.Dey M, Patra S, Su LY, Segall AM