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Estrogen and progesterone imbalances lead to a continuum of estrogen dominance conditions including PMS, endometriosis, PCOS, cystic breast disease, and irregular menstrual periods.Estrogen increases thyroid-binding proteins in the bloodstream

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The explicit hypolipidemic effect observed with NSS matched recent research indicating that Nigella sativa seed administration markedly improves the lipid profile (53)

Acyl-CoA synthetase long-chain family member 4 (ACSL4) preferentially activates polyunsaturated fatty acids such as arachidonic and adrenic acids, forming acyl-CoA derivatives that are incorporated into phosphatidylethanolamine (PE) by membrane-bound O-acyltransferases (MBOATs) [84,85]