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Another peculiar sex difference was reported in an Iranian observational study ( n = 3362) where lower dietary riboflavin levels were associated with anxiety and depression in middle-aged men ( n = 1403), and psychological distress in middle-aged women ( n = 1959) 61
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The findings highlight the mechanisms by which inflammatory cytokines, stress kinases, and reactive oxygen species (ROS) interfere with insulin signaling pathways, leading to impaired glucose metabolism and organ dysfunction

doi: 10.3390/molecules26164913 106