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PLP is a cofactor for the synthesis of several neurotransmitters including serotonin, the catecholamines dopamine, norepinephrine, and epinephrine [critical enzyme is aromatic L-amino acid decarboxylase (AADC) which is encoded by the DDC gene and is more commonly referred to as DOPA decarboxylase], and -aminobutyric acid, GABA (critical enzyme is glutamic acid decarboxylase, GAD)

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Micronutrients/mirs/atp networking in mitochondria: clinical intervention with ferroptosis, cuproptosis, and calcium burden

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In addition, ROS can regulate collagen metabolism, resulting in skin relaxation, deepening of wrinkles, and decreased skin elasticity [26]

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