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Methodology Using resources such as Elsevier, Science Direct, Scopus, PubMed, and Web of Science, we performed a literature search and identified recent related literatures

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The second retrospective study evaluated DILI cases diagnosed between 1994 and August 2012 and retrieved from the Spanish Hepatotoxicity Registry (REH)

Journals such as the American Journal of Clinical Nutrition, Journal of Agricultural and Food Chemistry, and Nature exhibit high citation figures, reflecting the significant impact and broad academic attention garnered by this research, indicative of a trend toward multidisciplinary cross-research

Based on the theory proposed during the development of methadone maintenance programs, addiction can be considered a metabolic disease, given that it is initiated by a disruption in metabolism and causes persistent neurochemical disturbances, leading to addiction 11,12