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Most people describe mild discomfort similar to any intramuscular or subcutaneous injection

Transcriptional and epigenetic regulation of PPARgamma expression during adipogenesis

5.3 Not Indicated for Treatment of Obesity Thyroid hormones, including Levothyroxine Sodium for Injection, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss

I wish I could share more on this but dosing protocols vary based on the practitioner who uses them