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Mitochondria as the specific site of intracellular melatonin production is generally supported by the published data and is consistent with the evolution of these organelles, which were derived from prokaryotes that presumably had the capacity of melatonin synthesis ( Figure 2 )

Sarcomatoid carcinoma of the lung: a predictor of poor prognosis

Jun 2010;120(6):1274-8

Katturajan R, Evan Prince S (2021) A role of connexin 43 on the drug-induced liver, kidney, and gastrointestinal tract toxicity with associated signaling pathways

While replenishing dopamine is fundamental to treatment, peripheral dopamine administration induces severe cardiovascular and gastrointestinal side effects and fails to reach the brain [219,220]