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HAP1 cells with a knockout of mitochondrial trans-2-enoyl-CoA reductase, an enzyme required for lipoic acid (LA) synthesis, were used as a positive control because the majority of DLAT is expected to be unlipoylated in these cells (confirmed by western blot in Supplementary Fig

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These are presented in detail in Section 4.1

It is essential for the enzymatic system that governs cell division and proliferation

Through gene editing, metabolic pathway reprogramming, or surface molecule modification of bacterial strains, engineered microorganisms achieve highly selective colonization within tumor tissues (Wang R