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In contrast, in a model of skin carcinogenesis, GPx-1-overexpressing mice have an accelerated pattern of lesion development, have more tumors per mouse, and have tumors with increased growth rates, as measured by BrdU labeling (238)

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Since preclinical studies have indicated that 3-THP is involved in fetal neurodevelopment, some authors have hypothesized that low levels of 3-THP during fetal life are related to a higher risk of ADHD, ASD disorders, or anxiety during childhood and adolescence (213)

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