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Description
Familial chylomicronemia syndrome is a rare genetic disorder estimated to affect 1 to 2 individuals per million and characterized by hypertriglyceridemia, which is caused by mutations in LPL or genes that regulate LPL function which include but are not limited to APOC2, APOA5, GPIHBP1, and lipase maturation factor 1 (LMF1) [19,20]

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LCAT can also influence APOA1 exchange dynamics resulting in migration of APOA1 from mature plasma HDL to yield reconstituted HDL discs with three molecules of APOA1 [70]

LNP sizes were in the range of 4060 nm in diameter over the whole range of lipid compositions (Fig

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