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Complementary preclinical angiogenesis models may include the chick chorioallantoic membrane assay, rodent Matrigel plug assays conducted under approved laboratory animal research protocols, and other standardized tissue-level models

If any side effects are experienced, they are mild and reversible

TABLE 2 General characteristics of the study groups

Drug delivery methods based on nanoparticles have proved to be an effective solution to these problems (Lee et al

Researchers found that -MSH had potent anti-inflammatory actions

In vitro studies have demonstrated that DFO can inhibit the degradation of type II collagen in osteoarthritis cartilage while also reducing the expression of inflammatory factors such as MMP-1, MMP-13, IL-1, and TNF- (Tchetina et al., 2016)