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Administration of the mtROS scavenger mitoTEMPO reversed cGAS-STING activation and alleviated liver injury, confirming in vivo for the first time that the liver-derived mtROS-cGAS-STING axis functions as a transcellular inflammatory signaling cascade (Chen et al., 2025)

Most patients received two injections (one cycle), but 21 underwent repeated cycle dosing

Estrogen(Archived) [PubMed] [Google Scholar] 48.Baetens D., Gran T., Mendonca B.B., Gomes N.L., De Cauwer L., Peelman F., Verdin H., Vuylsteke M., Van der Linden M., Atay Z., et al

This mislocalization increases cytosolic PUFA esterification, generating lipid peroxides that promote ferroptosis in neighboring epithelial cells, reinforcing the immune-epithelial crosstalk within the axis

Simultaneously, ferroptosis may be involved in the progression of cardiac autonomic neuropathy (DCAN) through the P2Y14 receptor (a new member of the metabolic receptor family), while P2Y14 targeting naringin can alleviate DCAN by promoting the NRF2-GPX4 pathway to eliminate ROS and inhibit ferroptosis (117) ( Figure 2 )