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The presence of two significant elements in the regulatory region of the MT-1 and MT-2 genes, namely, the TATA box (serving as the core promoter element) and multiple cis-acting response elements, including metal-responsive elements (MREs) and antioxidant-responsive elements (AREs), drives their expression [32]

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Mitophagy When repair mechanisms fail to adequately clear or compensate the underlying damage, mitochondria undergo a selective autophagic event termed mitophagy, wherein dysfunctional mitochondria are eliminated prior to cytotoxicity (123)