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Hyperglycemia and the ensuing glucotoxicity exert their deleterious effects via myriad mechanisms, including ROS stress, ER stress, inflammation, and hypoxia 28

The commenter does not state what other services beyond skilled nursing are involved in the provision of home-based IVIG therapy

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Microvascular complications are equally driven by oxidative damage i.e., in diabetic retinopathy, ROS-induced VEGF overexpression through HIF-1 stabilization leads to pathological angiogenesis (Kowluru and Mishra, 2017), while in diabetic nephropathy, podocyte injury results from NOX4-derived O 2 and mitochondrial ROS-mediated apoptosis (Jha et al., 2024)

Laboratories frequently apply synthetic modifications to these molecules