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Abbreviations APAP: acetaminophen, gamma-GT: gamma-glutamyltranspeptidase, GCLC: glutamyl-cysteine ligasecatalytic subunit GPx: GSH peroxidases, GSH: glutathione, GSSG: oxidized GSH, GST: glutathione S-transferase, HIC: hemin-induced cytotoxicity, Keap1: Kelch-like ECH associated protein 1, MRP: multidrug-associated resistance protein, MS: mass spectrometry NAC: N-acetyl cysteine, NAPQI: N-acetyl p-benzoquinone imine, Nrf2: nuclear factor erythroid 2-related factor-2, PGAs: prostaglandins, RBCs: red blood cells, RNS: reactive nitrogen species, ROS: reactive oxygen species, TF: transcription factor