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Alpha-synuclein (-Syn), abundantly expressed within the brain and implicated in numerous pivotal synaptic processes of neurons, can bind to Fe 2+ or Fe 3+ to fabricate the -Syn-iron complex

Journal Pharmacology 922, 174867

Fazio A, Bordoni D, Kuiper JWP, Weber-Stiehl S, Stengel ST, Arnold P, et al

Soil-Plant-Microbe Interactions in Salt-affected Soils

These comprehensive cytoprotective proteins encoded by NRF2-target genes are essential for protection against a variety of toxic and oxidative insults and therefore many diseases that have oxidative stress as underlying pathological features, including cardiovascular disease, metabolic syndrome, neuronal degeneration, autoimmune disorders, and cancer

ALA pretreatment of breast cancer cell lines increases cell sensitivity to ionizing radiation and blocks transforming growth factor beta signaling inhibiting the migration and invasion of metastatic breast cancer cells [91]