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First, it works through beta-3 adrenergic receptors, which are predominantly expressed in adipose tissue with limited expression in most other tissues

Johnson TO, Akinsanmi AO, Ejembi SA, Adeyemi OE, Oche JR, Johnson GI, Adegboyega AE (2023) Modern drug discovery for inflammatory bowel disease: the role of computational methods

8 , e1000514 (2010)

Stable isotope tracing experiments showed a significant contribution of l-serine-derived carbon into nucleotide, S -adenosylmethionine, and GSH biosynthesis, suggesting that l-serine contributes to energy balance, methylation, and redox biology of activated macrophages

Clinical translation would require trials in cardiac patient populations with appropriate safety monitoring given theoretical concerns about blood pressure effects and vascular remodeling