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Description
MALT1 hydrolase, located upstream of the Gln degradation pathway promoting GLS1-mediated Gln catabolism via c-Jun1, promoted epigenetic modification of H3K9Ac and H3K27Ac of the IL17A gene promoter, enhancing the chromatin accessibility of RORt (RORC), thus exacerbating IL-17A expression and ultimately causing immune peripheral blood imbalance and psoriatic lesions (79)
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Impact of obesity on bone metabolism
In the mitochondria of M6 muscle cells, for example, CD147 was found to interact with MCT1 29
In their study, Klider et al
