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Other enzyme defects in the heme biosynthesis pathway are associated with porphyria, classified as either erythropoietic or hepatic based on the site of intermediate product accumulation 188

Protein thiol homeostasis: Glutathione maintains proteins in their reduced (functional) state through S-glutathionylation, a reversible post-translational modification that regulates protein activity under oxidative stress [2]

Antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) scavenge free radicals, including those produced by biological processes (Abulfadl et al