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Common SLC7A11 inhibitors including sulfasalazine, erastin, sorafenib, and IKE, have shown good antitumor effects in various cancer models (Yang J

IGF-1 stimulates both the proliferation and differentiation of skeletal muscle satellite cells, leading to significant increases in muscle fiber size. Florini et al., Endocrine Reviews 2

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Ruiz-Tamayo I, Franch-Nadal J, Mata-Cases M, Mauricio D, Cos X, Rodriguez-Poncelas A, Barrot J, Coll-de-Tuero G, Mundet-Tudur X

Its bioavailability ranges from 25% to 40%

Cancer Res Stat Treat (2020) 3(4):767