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To investigate, Huiying Li, a molecular pharmacologist at the University of California-Los Angeles, and her team decided to focus on high levels of B12 as a possible culprit, based on research from the past six decades that's linked it to higher instances of the condition

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GHK-Cu stimulates fibroblasts to produce collagen I, collagen III, decorin, and glycosaminoglycans, the structural components of healthy dermis

The authors used affinity mediated DNA-encoded library selection against a privileged scaffold to identify a compound with potent inhibition against human glutathione S-transferase Mu 2

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Fukuda et al., 1994