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Song C., Peng W., Yin S., et al., Melatonin Improves Ageinduced Fertility Decline and Attenuates Ovarian Mitochondrial Oxidative Stress in Mice, Scientific Reports 6 (2016): 35165

Cortistatin promotes this synchronization directly Homeostatic regulation -- preprocortistatin mRNA is upregulated after sleep deprivation and follows a circadian rhythm, indicating that cortistatin functions as an endogenous homeostatic sleep factor BDNF-dependent expression -- brain-derived neurotrophic factor regulates cortistatin expression in an activity-dependent manner, linking neuronal activity during wakefulness to subsequent sleep drive Cortistatin's receptor pharmacology is well-defined

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