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Growth hormone is naturally secreted in pulses during slow-wave sleep, with the largest pulse occurring in the first few hours after falling asleep

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Initial treatment may involve daily injections, followed by a weekly or monthly maintenance schedule based on patient response

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In endothelial and epithelial cells, binding to FcRn results in IgG and albumin being recycled either back to the apical cell surface or, in polarized epithelial cells, transported across the cells in receptor-mediated transcytosis