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Doscherholmen A, Hagen PS

Dysbiosis destroys the integrity of intestinal barriers, thus making the mucosa permeable to pathological organisms and leading to cell death among small intestinal cells such as Paneth and goblet cells (70, 71)

The methylation status of these genes can be influenced by hormonal cues such as PGF2 or metabolic stress

Additionally, SLE is a typical autoimmune disease, and the overactivation of CD4 + T lymphocytes is a feature of SLE ( + T cells are over differentiated into pathogenic Th1 and Th17 cells, whereas Treg cells are suppressed (49, 50)

The results revealed that the levels of pro-inflammatory cytokines IL-6, IL-12, and TNF- secreted by cells treated with NP4 were 1.45, 5, and 1.78 times higher than those secreted by cells treated with NP2, respectively, further confirming the activation of macrophages

Optical imaging of cleavage stage bovine embryos using hyperspectral and confocal approaches reveals metabolic differences between on-time and fast-developing embryos