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A literature search was conducted from January 2000 to December 2022 using multiple databases including Web of Science, Wiley, Springer, PubMed, Elsevier Science Direct, Google Scholar, the Core Collection, Scopus, and the Cochrane Library to collect and evaluate peer-reviewed literature regarding the neuroprotective role of metformin against DM-induced neurodegenerative events

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Many factors can increase cellular exposure to oxidative insult, and therefore increase cellular consumption of nutrientssuch as glutathionethat provide antioxidant activity

At higher doses, side effects can be dangerous and life-threatening, such as seizures, loss of consciousness, depression of respiratory and circulatory centers, slow heart rate, and even cardiac arrest