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Athanassakis I, Dionyssopoulou E, Papanikou S, Evangeliou A, Vassiliadis S

Prospective cohort studies have shown that long-term elevated plasma TMAO levels significantly increase the risk of cardiovascular disease

95 percent CI 0.21-0.58

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MiR-122 was the first miRNA identified as tissue-specific, and it is the most abundant in liver involved in lipid metabolic reprogramming 83

After TMAO treatment, in tumor-associated macrophages, stimulatory markers like MHC-I, MHC-II, and CD86 are upregulated, while the anti-inflammatory marker Arg1 is downregulated (79)