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For NOACs: measure bleeding time or anti-Xa levels at baseline and day 7 post-peptide-introduction, since NOACs lack routine lab monitoring

On the basis of the complicated pathogenic mechanisms and unsatisfactory therapeutic outcome of DKD, determining the exact pathogenesis and developing appropriate treatment methods are quite necessary

A higher Bcl-2/Bax ratio means cells are more likely to survive

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Recently HNE has been shown to induce GCLC with concentrations found in human plasma, suggesting that the basal GCLC expression is under regulation by products of lipid peroxidation (Zhang et al., 2007)

doi: 10.1016/j.jim.2022.113378 27 GharaviATHanjaniNAMovahedEDoroudianM