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Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation

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However, given that ANGPTL3 activity is positively correlated to increased levels of phospholipid-rich HDL, which is highly active at cholesterol transport, there may be risks to blocking ANGPTL3 activity entirely

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Hepatic protein and mRNA levels were assessed using western blot analysis (Figure 3A) and qRT-PCR (Figure 3H), respectively