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Although paraquat may not be an efficient inhibitor of mitochondrial complex I, and so does not affect dopamine uptake [87,88], it does cause -synuclein aggregation in C57Bl/6 mice, and alters Parkin solubility, decreasing proteasome activity and causing cellular damage [87]

In biological terms, peptide stacking combines compounds that activate different molecular pathways

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Mutagenesis 30 , 771784 (2015)

In toxin-based models (MPTP or 6-OHDA), flavonoids prevent dopaminergic neuron dysfunction by preserving dopamine levels, reducing oxidative damage, and maintaining tyrosine hydroxylase (TH) protein expression (18)

In the present study, alignment analysis revealed that in chloroplastic/mitochondrial-related GPXs, the transit peptide sequences formed the first 5090 amino acid residues from the N-terminal site while in extra cellular/plasma membrane-related GPXs, residues of the first 2050 amino acid from N-terminal region contained the putative transit peptide