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Introduction Valproic acid (VPA) is a broad-spectrum antiepileptic drug (AED) that has been used for more than 30 years and is effective in the treatment of many different types of partial and generalized epileptic seizure

Bachmeier who provided training and advice for brain processing technique and cerebrovascular uptake studies

Therefore, it is expected to become the next generation of new antidepressants with fewer side effects (79)

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This article will review the role and mechanism of gut microbiota and its metabolites in the occurrence and development of atherosclerosis, myocardial infarction, heart failure, and hypertension