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These are not randomized controlled trials

found that laminarin treatment in HFD mice decreased body weight gain with an improved Firmicutes/Bacteroidetes ratio, enriched beneficial bacteria ( Clostridium cluster XIVa , Parabacteroides, and Bacteroides ), and reduced the abundance of potentially pathogenic bacteria ( Clostridium _XIVb and Clostridium _XI)

However, in one study in mice with mild ulcerative colitis, lipoic acid actually increased oxidative damage to the colon and liver [102]

Increased hemolysis due to defective erythropoiesis can lead to jaundice, serving as a potential indicator of the condition

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