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Damage to the motor neurons, which are linked to movement, can lead to weakened muscles, making it difficult to get around

Lysosomal acid lipase-deficient mice: depletion of white and brown fat, severe hepatosplenomegaly, and shortened life span

However, given the lower intracellular GSH:GSSG ratio after IL-13 stimulation, it is difficult to determine the proportionate role that loss of GSH plays in downstream T2-pathway mRNA/protein expression

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Evidence of this is presented in a study that looked at administration of oral liposomal GSH at 2 doses of 500 mg and 1000 mg per day in 12 healthy adults

doi: 10.1016/j.yfrne.2007.08.001