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Briefly, GH binding to preformed dimeric GHR - JAK2 complexes introduces structural changes in the receptor complex that separates JAK2 inhibitory and kinase active sites and enables trans-phosphorylation of the two JAK2 molecules (reviewed in (59)

This distinction matters because FDA approval involves a formal review of safety, effectiveness, manufacturing quality, labeling, and intended use

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Most effective results are seen with subcutaneous delivery due to direct absorption