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Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation

In particular, we have developed and tested preclinical compounds, such as INF-4E, INF195, and INF200, which reduce NLRP3 activation, improve post-ischemic cardiac function, and decrease infarct size [59, 60, 145]

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doi:10.1146/annurev.bi.52.070183.003431 Mezzetti F, Vero L de, Giudici P (2014) Evolved Saccharomyces cerevisiae wine strains with enhanced glutathione production obtained by an evolution-based strategy