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There have also been reports of lipase catalysis where the reaction proceeds with solvent quantities of one of the reagents 3,12,13 , where the lipases are typically present as either a lyophilized powder 12,13,26 , or immobilized on a substrate 2,3,8,10,27,28 , but there are no examples of molecularly dispersed enzymes catalysing reactions in the complete absence of a solvent

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