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In particular, glutathione (GSH) depletion is a common feature of apoptotic cell death triggered by a wide variety of stimuli including activation of death receptors, stress, environmental agents, and cytotoxic drugs

10.1038/nature09146

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Traynelis SF, et al

In the normal physiological state (Figure 3a), GSH is produced by the condensation of the amino acids glutamate and cysteine to form the dipeptide -glutamylcysteine, which is catalyzed by the enzyme, -glutamyl cysteine synthetase.The dipeptide then condenses with the amino acid glycine to form the tripeptide GSH which is catalyzed by the enzyme GSH synthetase

HK2 expression is significantly elevated in most HCC cell lines and tumor tissues compared to normal cell lines and tissues (225)