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doi: 10.3389/fmed.2022.813204 9

Zinc also regulates the endolysosomal tethering machinery through the HOPS complex, whose VPS18 and VPS41 subunits contain zinc-binding RING domains essential for heterodimer formation and complex stability, which is critical for autophagosomelysosome and endosomelysosome fusion 104

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Vitamin B12, together with folic acid, plays a crucial role here: if there is a deficiency, the cells cannot divide properly, resulting in oversized, immature blood cells

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