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In the presence of free ions of metals with a higher binding affinity, such as Cd 2+ or Hg 2+ , or of metal ions in conjugate forms, such as the glutathione-Cu(I) [148] and the glutathione-Cd [149] conjugates, these metals bind MT thiol groups and the bound Zn(II) is released [150]

Cullen KR, Klimes-Dougan B, Westlund Schreiner M, Carstedt P, Marka N, Nelson K, et al

Another derivative, HHQ16, exhibited substantial efficacy in improving cardiac function, notably increasing the left ventricular ejection fraction (LVEF) and left ventricular shortening fraction (LVFS) at a dose of 10 mg/kg

Science 325 , 11391142 (2009)

Du XL, Edelstein D, Rossetti L, Fantus IG, Goldberg H, Ziyadeh F, et al

Takida, S